| 窒息后缺氧缺血性脑病新生儿脐血NSE变化的意义 |
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| 引用本文： | 贾丽霞,王红英,刘冬青.窒息后缺氧缺血性脑病新生儿脐血NSE变化的意义[J].中国妇幼保健,2007,22(15):2073-2074. |
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| 作者姓名： | 贾丽霞 王红英 刘冬青 |
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| 作者单位： | 河北省邯郸市第一医院儿科,056002 |
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| 摘 要： | 目的:研究窒息后缺氧缺血性脑病(HIE)新生儿脐血神经元特异性烯醇化酶(NSE)的变化及临床意义。方法:同期足月正常新生儿26例为对照组,1分钟Apgar评分<7分的窒息新生儿58例,其中36例为非HIE组,22例为HIE组。采用放射免疫法测定脐血NSE水平。结果:窒息后发生HIE组的NSE水平为(24.13±3.82)μg/L,高于对照组(13.24±2.84)μg/L,且高于窒息后未发生HIE组的NSE水平(14.68±3.30)μg/L(P均<0.05)。结论:检测窒息后脐血NSE水平可早期预测HIE发生,作为早期诊断HIE的一个指标。
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| 关 键 词： | 窒息 缺氧缺血性脑病 脐血 新生儿 |
| 文章编号： | 1001-4411（2007）15-2073-02 |
| 修稿时间： | 2006-07-14 |
Changes of NSE in umbilical cord blood of aspbyxial neonates with hypoxic ischemic encephalopathy and its clinical significance |
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| JIA Li-Xia,WANG Hong-Ying,LIU Dong-Qing.Changes of NSE in umbilical cord blood of aspbyxial neonates with hypoxic ischemic encephalopathy and its clinical significance[J].Maternal and Child Health Care of China,2007,22(15):2073-2074. |
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| Authors: | JIA Li-Xia WANG Hong-Ying LIU Dong-Qing |
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| Institution: | Department of Internal Pediatrics, The First Hospital of Handan City, Handan 056002, China |
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| Abstract: | Objective:To study clinical significance of NSE in umbilical cord blood of asphyxial neonates with hypoxic ischemic encephalopathy.Methods:Twenty-six cases of healthy infants were regarded as control group.Fifty-eight cases of asphyxial neonates were divided two groups, 36 cases without HIE and 22 cases with HIE.NSE levels in umbilical cord blood of three groups were measured with RIA.Results:NSE levels in umbilical cord blood of group with HIE(24.13±3.82 μg/L) were significantly higher than that of control group(13.24±2.84 μg/L)(P<0.05),and that of group without HIE(14.68±3.30 μg/L)(P<0.05).Conclusion:To measure NSE level in umbilical cord blood of asphyxial neonates may be helpful in the early diagnosis of asphyxial neonates with HIE. |
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| Keywords: | Asphyxia Hypoxic Ischemie Encephalopathy(HIE) Umbilical cord blood NSE |
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