表没食子儿茶素没食子酸酯对2型糖尿病大鼠生化指标的影响

目的:观察表没食子儿茶素没食子酸酯(epigollatecatechin gallate,EGCG)对2型糖尿病大鼠血液生化指标的影响。方法:采用链脲佐菌素联合高脂饮食复制2型糖尿病大鼠模型,Wistar大鼠造模后随机分为正常对照组、模型对照组、EGCG大、中、小剂量[50、20、10 mg/(kg·d)]组治疗4周后。检测血清中门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆固醇(TCHO)、甘油三酯(TG)、尿素氮(UREA)、肌酐(CREA)变化。结果:与对照组比较,三组EGCG治疗组大鼠AST、ALT、UREA和CREA水平明显降低(P<0.05,P<0.01);低浓度EGCG组对TCHO的影响无统计学差异(P>0.05),中、高浓度EGCG组TCHO、TG的影响有统计学意义(P<0.05)。结论:EGCG具有改善血脂紊乱,保护肝肾功能的作用。

Effect of epigallocatechin gallate on blood biochemical indexes in type 2 diabetes mellitus rats

Objective: To study the effects of epigallocatechin gallate( EGCG) on blood biochemical indexes of type 2 diabetes mellitus( T2DM) rats. Methods: The combination of streptozotocin and high-fat diet was adopted to copy the model of T2 DM. Wistar rats were randomly divided into model control group,diabetic model treated with EGCG[50,20,10 mg /( kg·d) ]and normal control group. The changes of AST,ALT,TCHO,TG,UREA and CERA of serum were measured at the end of the 4thweek. Results: Compared with the model group,the AST,ALT,UREA and CREA decreased significantly in the three EGCG groups.( P < 0. 05,P < 0. 01). There is no significant statistic difference of the influence on TCHO in the low concentration EGCG group( P > 0. 05). There are significant statistic differences of the influence on TCHO and TG in the medium and high concentration EGCG groups( P < 0. 05). Conclusion: EGCG can decrease blood lipid and protect liver and kidney.