苦碟子联合缬沙坦治疗老年早期糖尿病肾病的临床观察

目的:探讨苦碟子注射液联合缬沙坦治疗老年早期糖尿病肾病临床疗效。方法:选择60例2型糖尿病合并糖尿病肾病患者,随机分为实验组和对照组各30例。对照组给缬沙坦80mg,1次/d,共14d。实验组在应用缬沙坦的基础上,加用苦碟子注射液40ml+生理盐水250ml静脉滴注,1次/d,共14d。观察其治疗前、后24h尿蛋白定量(24U-TP)、血清胱抑素C(Cys-C)和肾功能变化,记录不良反应。结果:治疗后实验组24U-TP、Cys-C较对照组明显下降,差异有统计学意义(P<0.05或P<0.01);治疗后两组BUN、Scr未增高,差异无统计学意义(P>0.05)。结论:苦碟子注射液联合缬沙坦治疗早期DN疗效优于对照组,且无明显不良反应。

Effect of Combination of Kudiezi Injection and Valsartan on Old Patients with Early Diabetic Nephropathy

Objective：To observe the effect of combination of Kudiezi injection and Valsartan on old patients with early diabetic nephropathy.Methods：60 patients of early diabetic nephropathy were divided into 2 groups：combination group（n=30） and control group（n=30）.Control group： Valsartan 80mg,once daily;combination group：Valsartan 80mg＋Kudiezi injection 40mg,once daily.Continuous course treatment of 14 days,Before and after the treatment,24U-TP、Cys-C,BUN,Scr were detected,and drug adverse reactions were also observed.Results：After continuous course treatment of 14 days,the 24U-TP、Cys-C of the 2 groups were both decreased（P0.01）.Compared with control group,combination group was decreased obviously（P0.05 or P0.01）.The BUN,Scr of the 2 groups had no statistically significant and the serious adverse reactions were not observed.Conclusion：Combination of Kudiezi injection and Valsartan could safely decrease the 24U-TP、Cys-C of early diabetic nephropathy in old patients.