The effect of RO15-1788 on cardiovascular depression caused by fentanyl and diazepam |
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Authors: | Takeshi Sone Toshimasa Kato Ikuo Tsukahara Tomokazu Harada Michio Yamamoto Alan Talbot |
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Affiliation: | (1) Department of Anesthesiology, Gifu University School of Medicine, Gifu, Japan;(2) Department of Anesthesiology, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC;(3) Department of Anesthesiology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500, Japan |
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Abstract: | Cardiovascular depression occuring when diazepam is combined with fentanyl has been investigated using the benzodiazepine antagonist RO15-1788 in the dog.After the initial administration of fentanyl (40mcg/kg), the mean arterial pressure (MAP) decreased to 89% of its control value. Following the administration of diazepam (1.2mg/kg), the MAP and the total peripheral resistance (TPR) decreased significantly, to 75% and 83% of their control values respectively. After the administration of RO15-1788 (0.4mg/kg), the MAP increased significantly to 90% and the TPR to 102% of their control values and, lastly, the administration of naloxone (40mcg/kg) increased the MAP to 108% of its control value. No relationship was found between the changes in the catecholamines and the changes in the MAP after the administration of fentanyl, diazepam, and RO15-1788.The mechanism of circulatory depression when diazepam was used with fentanyl is interpreted as being a peripheral vasodilatory effect of diazepam acting by way of the benzodiazepine receptors since RO15-1788 was found to antagonize this effect.(Sone T, Kato T, Tsukahara I et al.: The effect of RO15-1788 on cardiovascular depression caused by fentanyl and diazepam. J Anesth 2: 69–76, 1988) |
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Keywords: | Ro15-1788 Diazepam Fentanyl Naloxone Catecholamine |
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