急性加重期COPD合并肺性脑病临床急救措施评估的研究

目的探讨急性加重期慢性阻塞性肺疾病（COPD）合并肺性脑病临床急救措施效果。方法选择2008年8月~2011年3月于我院治疗的慢性阻塞性肺疾病急性加重期（AECOPD）合并肺性脑病患者68例,将其分为治疗组（35例）和对照组（33例）,对照组采用常规治疗和BiPAP通气,治疗组在对照组治疗方法的基础上加用纳络酮。结果治疗组患者意识障碍改善率高于对照组（χ2=6.000,P=0.014）,气管插管率较对照组明显降低（χ2=4.088,P=0.043）,与对照组相比,治疗48 h后治疗组患者PaO2、PaCO2均有明显改善（P〈0.05）。结论 BiPAP联合呼吸兴奋剂治疗AECOPD合并肺性脑病较单独使用BiPAP临床疗效更佳

Clinical study of evaluation on clinical first aid measures in chronic obstructive pulmonary disease of acute exacerbation combined with pulmonary encephalopathy

Objective To observe the clinical efficacy of clinical first aid measures in chronic obstructive pulmonary disease of acute exacerbation(AECOPD) combined with pulmonary encephalopathy.Methods 68 patients with AECOPD in our hospital from August 2008 to March 2011 were randomly divided into treatment group and control group.The treatment group was treated with BiPAP,as well as conventional therapeutic managements and naloxone administration,whereas,control group only received BiPAP and conventional intervention.Results The improved rate of consciousness disorder in the treatment group was higher than that in the control group(χ2 =6.000,P = 0.014),whereas the tracheal intubations rate was lower than that in the control group(χ2 =4.088,P = 0.043).Compared with control group,PaO2 and PaCO2 of patients in treatment group were obviously improved therapy after 48 hours(P < 0.05).Conclusion The clinical efficacy of BiPAP combined respiratory stimulant is better than that with BiPAP alone in the treatment of AECOPD combined pulmonary encephalopathy.