| 人体癌胚抗原相关细胞黏附分子1的结构与功能 |
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| 引用本文： | 叶秋芳. 人体癌胚抗原相关细胞黏附分子1的结构与功能[J]. 医学综述, 2012, 18(12): 1851-1854 |
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| 作者姓名： | 叶秋芳 |
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| 作者单位： | 昆明医科大学第一附属医院心内科,分子心血管病研究室,昆明,650032 |
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| 基金项目： | 国家自然科学基金,云南省中青年学术技术带头人后备人才资助项目,云南省教育厅重大专项,昆明医学院教研教改项目 |
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| 摘 要： | 人癌胚抗原相关细胞黏附分子1(CEACAMl)是广泛表达于中性粒细胞、巨噬细胞、内皮细胞、上皮细胞及淋巴细胞表面的Ⅰ型跨膜糖蛋白,属癌胚抗原家族免疫球蛋白超家族分子,胞膜外区有Ig样结构域,CEACAM1-L型具有两个免疫受体酪氨酸抑制性基序,其生物学功能包括免疫调节、促进血管形成、调节血管重构、参与细胞凋亡调控、促进腺体管腔形成及调控胰岛素的清除,同时CEACAM1也是致病微生物的黏着受体。
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| 关 键 词： | 癌胚抗原相关细胞黏附分子1 免疫调节 肿瘤转移 血栓形成 |
Structure and Function of Human Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 |
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| YE Qiu-fang. Structure and Function of Human Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1[J]. Medical Recapitulate, 2012, 18(12): 1851-1854 |
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| Authors: | YE Qiu-fang |
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| Affiliation: | 2.(Laboratory of Molecular Cardiology,Department of Cardiology,the First Affiliated Hospital Of Kunming Medical College,Kunming 650032,China;2.Department of Computer Science,the Faculty of Basic Medicine,Kunming Medical College,Kunming 650031,China) |
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| Abstract: | Human carcinoembryonic antigen-related cellular adhesion molecule 1(CEACAM1)is a member of the carcinoembryonic antigen family(CEA)which is a type I-transmembrane glycoprotein broadly expressed on the surface of cells including macrophages,neutrophilic granulocyte,lymphocyte,epithelial,and endothelial cells.It is an adhesion molecule of immunoglobulin superfamily.The extracellular domain of CEACAM1 contains IgG-like structure.The long form of CEACAM1 protein has two immunoreceptor tyrosine-based inhibitory motifs(ITIMs)that have crucial roles in immuno-regulation,vascular neogenesis,vascular remolding,cell apoptosis regulation,gland lumen formation and insulin clearance.CEACAM1 is also a receptor for pathogenic bacteria and viruses. |
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| Keywords: | Carcino-embryonic antigen-related cellular adhesion molecule 1 Immuno-regulation Tumour metastasis Thrombosis |
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