神经元凋亡在帕金森病中的作用

帕金森病(PD)以静止性震颤、肌肉僵硬、运动迟缓和姿势不稳为临床特征,是一种中老年人常见的中枢系统退行性疾病,主要病理变化为黑质部位的多巴胺能神经元变性导致黑质纹状体多巴胺含量减少以及路易小体形成。PD的病因和发病机制至今尚未明确,凋亡在PD发病机制中占有十分重要的地位,现就神经元凋亡在PD中的作用予以综述。

Role of Neuronal Apoptosis in Parkinson Disease

The main clinical features of Parkinson disease(PD)include static tremor,rigidity,bradykinesia and postural instability.It is a common neurodegenerative disease in central nervous system of the middle and old aged people.The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra,resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum and the Lewy body formation.The etiology and pathogenesis of PD are still indefinite.Apoptosis is intimately linked to other components of neurodegenerative process.Here is to make a review on the possible role of neuron apoptosis in PD.