| 间接性颞下颌关节损伤后IL-8的表达及其意义 |
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| 引用本文： | 胡开进,周树夏,戴毅敏,孙庆妹.间接性颞下颌关节损伤后IL-8的表达及其意义[J].实用口腔医学杂志,2002,18(4):304-306. |
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| 作者姓名： | 胡开进 周树夏 戴毅敏 孙庆妹 |
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| 作者单位： | 西安第四军医大学口腔医学院,710032 |
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| 基金项目： | 陕西省科学技术研究发展计划项目 (2 0 0 0K1 4 G1 3) |
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| 摘 要： | 目的：通过观察羊颞下颌关节（TMJ）间接创伤后不同时期髁突软骨中IL-8的表达，探讨IL-8在TMJ创伤后导致TMJ骨关节病过程中的作用。方法：用自制撞击装置造成山羊双侧颞颌关节间接性创伤，分别于伤后2h,7d,1月，3月取材，并以正常TMJ作为对照，用免疫组化法进行观察。结果：TMJ创伤后髁突软骨中IL-8的表达明显强于正常对照组，其着色程度越靠近结构破坏区越明显。结论：IL-8在TMJ创伤后导致TMJ骨关节病过程中起重要作用。
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| 关 键 词： | 间接性颞下颌关节损伤 IL－8 炎症反应 免疫组织化学 发病机制 动物实验 |
| 文章编号： | 1001-3733(2002)-04-0304-03 |
| 修稿时间： | 2001年1月9日 |
Expression of interleukin-8 in the condyle of temporomandibular joint after indirect trauma |
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| Hu Kaijin,Zhuo Shuxia,Dai Yimin,et al..Expression of interleukin-8 in the condyle of temporomandibular joint after indirect trauma[J].Journal of Practical Stomatology,2002,18(4):304-306. |
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| Authors: | Hu Kaijin Zhuo Shuxia Dai Yimin |
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| Institution: | Hu Kaijin,Zhuo Shuxia,Dai Yimin,et al. Department of Oral Maxillofacial Surgery,College of Stomatology,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | Objective: In order to understand the roles of interleukin-8(IL-8) in the pathogenesis of temporomandibular joint(TMJ) after indirect trauma.Methods: Trauma to the TMJ in 25 goats was achieved under an impact to the right and left mandibular angle with a self-made device. The goats were killed 2 h, 7 d, 1 month and 3 months after impact respectively. The expression of interleukin-8 in the condyle of TMJ was observed by immunohistochemical stainning. The normal TMJs were used as controls. Results: The positive expression of IL-8 was observed in the condyle of TMJ after indirect trauma. The stronger expression was observed in the destroyed area of condyle.Conclusion: IL-8 may play an important role in the pathogenesis of TMJ after indirect trauma. |
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| Keywords: | Temporomandibular Joint Wound and injuries Interleukin-8 Immunohistochemistry |
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