Role of the endothelium in inflammatory bowel diseases |
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| Authors: | Cromer Walter E Mathis J Michael Granger Daniel N Chaitanya Ganta V Alexander J Steven |
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| Affiliation: | Walter E Cromer,J Michael Mathis,Department of Cellular Biology and Anatomy,LSU Health Sciences Center-Shreveport,1501 Kings Highway,Shreveport,LA 71130-3932,United States Daniel N Granger,Ganta V Chaitanya,J Steven Alexander,Department of Cellular and Molecular Physiology,United States |
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| Abstract: | Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokin... |
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| Keywords: | Microvasculature Endothelium Inflammation Nitric oxide Adhesion molecules Crohn's disease Ulcerative colitis Cytokines Chemokines Growth factors |
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