Protection of the liver against CCl4-induced injury by intramuscular electrotransfer of a kallistatin-encoding plasmid |
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| Authors: | Diao Yong Zhao Xiao-Feng Lin Jun-Sheng Wang Qi-Zhao Xu Rui-An |
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| Affiliation: | Yong Diao,Xiao-Feng Zhao,Qi-Zhao Wang,Rui-An Xu,Institute of Molecular Medicine,Huaqiao University,Quanzhou 362021,Fujian Province,China Jun-Sheng Lin,Centre for Reproduction and Genomics,AgResearch,Invermay,Mosgiel 9053,New Zealand |
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| Abstract: | AIM:To investigate the effect of transgenic expression of kallistatin(Kal) on carbon tetrachloride(CCl 4)induced liver injury by intramuscular(im) electrotransfer of a Kal-encoding plasmid formulated with poly-Lglutamate(PLG).METHODS:The pKal plasmid encoding Kal gene was formulated with PLG and electrotransferred into mice skeletal muscle before the administration of CCl 4.The expression level of Kal was measured.The serum biomarker levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),ma... |
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| Keywords: | Kallistatin Gene delivery systems Electroporation Drug formulation Liver injury |
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