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Role of conventional therapies in the era of biological treatment in Crohn’s disease
作者姓名:Paolo Gionchetti  Carlo Calabrese  Rosy Tambasco  Ramona Brugnera  Giulia Straforini  Giuseppina Liguori  Giulia Spuri Fornarini  Donatella Riso  Massimo Campieri  Fernando Rizzello
作者单位:Department of Clinical Medicine;University of Bologna;40138 Bologna;Italy;
基金项目:Supported by MIUR, PRIN 2008 (MC)
摘    要:Outstanding progress regarding the pathophysiology of Crohn’s disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when available,that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease ...

关 键 词:Crohn’s  disease  Sulfasalazine  5-Aminosalicylic  acid  Azathioprine  6-Mercaptopurine  Biological  therapies  Anti-tumor  necrosis  facto-α  
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