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| Role of conventional therapies in the era of biological treatment in Crohn’s disease | |
| 作者姓名： | Paolo Gionchetti Carlo Calabrese Rosy Tambasco Ramona Brugnera Giulia Straforini Giuseppina Liguori Giulia Spuri Fornarini Donatella Riso Massimo Campieri Fernando Rizzello |
| 作者单位： | Department of Clinical Medicine;University of Bologna;40138 Bologna;Italy; |
| 基金项目： | Supported by MIUR, PRIN 2008 (MC) |
| 摘 要： | Outstanding progress regarding the pathophysiology of Crohn’s disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when available,that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease ... |
| 关 键 词： | Crohn’s disease Sulfasalazine 5-Aminosalicylic acid Azathioprine 6-Mercaptopurine Biological therapies Anti-tumor necrosis facto-α |
| 本文献已被 CNKI 等数据库收录！ | |