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Pathogenesis of occult chronic hepatitis B virus infection |
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| Authors: | de la Fuente Rocio Aller Gutiérrez María L Garcia-Samaniego Javier Fernández-Rodriguez Conrado Lledó Jose Luis Castellano Gregorio |
| Institution: | Rocio Aller de la Fuente,Gastroenterology,Hospital Clinico Universitario Valladolid,Institute of endocrinology and Nutrition,Medical School,University of Valladolid,47003 Valladolid,Spain María L Gutiérrez,Service of Gastroenterology,Hospital Universitario Fundación Alcorcón,Av Budapest-1,28922 Alcorcón,Madrid,Spain Javier Garcia-Samaniego,Gastroenterology Department,Hospital Carlos III,c/Sinesio Delgado,28029 Madrid,Spain Conrado Fernández-Rodriguez,Hospital Universitario Fundac... |
| Abstract: | Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DN... |
| Keywords: | Occult hepatitis B virus infection Hepatitis B virus-DNA Anti-HBc alone Hepatitis B virus Hepadnaviral hepatitis Occult viral persistence Primary occult infection Secondary occult infection Virus reactivation |
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