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| 纳米氧化锆强韧化高孔隙率磷酸钙人工骨细胞支架生物学评价 | |
| 引用本文： | 戴伯军,李家顺,贾连顺,吕宏,陈岗,叶晓健,蔡舒,张立德. 纳米氧化锆强韧化高孔隙率磷酸钙人工骨细胞支架生物学评价[J]. 中国矫形外科杂志, 2004, 12(13): 998-1001 |
| 作者姓名： | 戴伯军 李家顺 贾连顺 吕宏 陈岗 叶晓健 蔡舒 张立德 |
| 作者单位： | 1. 第二军医大学附属长征医院,上海凤阳路415号,200003 2. 天津大学材料学院,天津,300072 3. 中科院固体所,合肥,230031 |
| 基金项目： | 国家自然科学基金资助项目 (编号 :30 1 70 954) |
| 摘 要： | 目的：对自行研制的纳米氧化锆强韧化高孔隙率磷酸钙人工成骨细胞支架[hyper-porosity Ca3(PO4)：bone cells frame／NM ZrO2 reinforced以下简称支架]的体外生物相容性进行评价。方法：采用细胞毒性试验、溶血试验和急性全身中毒试验3种方法。结果：(1)培养的L929成骨细胞经支架浸提液处理后形态良好，增值旺盛，材料毒性评级为0级；(2)溶血率为2．23％(小于5％)，符合溶血试验标准要求；(3)无急性全身中毒反应。结论：支架复合物具有良好的生物相容性。 |
| 关 键 词： | 纳米 氧化锆 磷酸钙 |
| 文章编号： | 1005-8478(2004)13-0998-04 |
Bio-compatibility of hyper-porosity Ca3(PO4)2 artificial bone cells frame reinforced by NM ZrO2 in vitro |
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| DAI Bo-jun,LI Jia-shun,JIA Lian-shun,et al.. Bio-compatibility of hyper-porosity Ca3(PO4)2 artificial bone cells frame reinforced by NM ZrO2 in vitro[J]. The Orthopedic Journal of China, 2004, 12(13): 998-1001 | |
| Authors: | DAI Bo-jun LI Jia-shun JIA Lian-shun et al. |
| Affiliation: | DAI Bo-jun,LI Jia-shun,JIA Lian-shun,et al.Department of Orthopaedics,Changzheng Hospital,the Second Military Medical University,Shanghai 200003 |
| Abstract: | Objective:To evaluate the bio-compatibility of hyper-porosity Ca 3(PO 4) 2 artificial bone cells frame reinforced by NM ZrO 2 in vitro.Method:The cytotoxicity,hemolysis and acute whole body toxicity were tested with standard method.Result:(1)There was no obvious change of attachment,morphology and proliferation after L929 mouse fibroblasts had been treated by extracts.The toxicity gradation of the material was 0,measured by a value of MTT assay;(2)Hemolysis ratio was 2.23%;(3)There was no obvious whole-body toxicity reaction.Conclusion:The hyper-porosity Ca 3(PO 4) 2 artificial bone cells frame reinforced by NM ZrO 2 is Bio-compatible to tissue cells. |
| Keywords: | Nanometer Zirconia(ZrO2) Calcium phosphate[Ca3(PO4)2] |
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