Ⅱ型糖尿病家系中一级亲属的脂质代谢紊乱与胰岛素抵抗

为研究II型糖尿病家系中一级亲属的脂质变化和胰岛素抵抗，对25个II型糖尿病家系中非糖尿病一级亲属，糖耐量减低者，糖尿病患者进行了空腹血糖，空腹胰岛素，总胆固醇，甘油三酯和高密度脂蛋白测定，根据公式计算低密度脂蛋白及胰岛素敏感指数，并与家系中非糖尿病非糖耐量减低同胞的配偶进行了比照，结果发现，一级亲属，糖耐量减低者，糖尿病患者甘油三酯较正常对照组高，高密度脂蛋白，胰岛素敏感指数较正常对照组低，此结果提示，II型糖尿病患者的一级亲属在未患糖耐量减低和糖尿病之前存在脂代谢紊乱和胰岛素抵抗。

Dyslipidemia and Insulin Resistance of first Clegrr Retatives in 2 Type Diabetes Mullitus Families

Aim　To investigate the changes of lipid and the insulin-resistance non diabetes first degree relatives of 2 type diabetes mullitus families.　Methods　The fasting insulin (FINS), total cholesteral (TC), triglyceride (TG) and high density lipoprotein (HDL) were measured in diabetes mullitus (DM) group, impaired glucose tolerance (IGT) group and non diabetes first degree relatives (FDR) group of 2 type diabetes mellitus families.　Their spouses were selected as control group.　The oral glucose tolerance test (OGTT) were conducted in all grops.　The insulin resistance were assessed by insulin sensitive index (ISI)=1/FPG (fasting plasme glucose) × FINS.　Results　TG in DM group, IGT group and FDR group was markedly elevated (P<0.01 and P<0.05）.　HDL level and ISI in DM group, IGT group and FDR group were lower (P<0.05 and P<0.01）.　Conclusion　Insulin resistance and lipid abnormalities appear early (before the development of IGT and DM) in first degree relatives of 2 type DM.