Efficacy of tolterodine on overactive bladder symptoms and sexual and emotional quality of life in sexually active women |
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Authors: | Rebecca Rogers Gloria Bachmann Zhanna Jumadilova Franklin Sun Jon D. Morrow Zhonghong Guan Tamara Bavendam |
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Affiliation: | (1) Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC10-5580 Albuquerque, NM 87131, USA;(2) University of Medicine and Dentistry of New Jersey-RWJMS, New Brunswick, NJ, USA;(3) Pfizer Inc, New York, NY, USA |
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Abstract: | We evaluated overactive bladder (OAB) symptoms and sexual and emotional health in sexually active women with OAB/urgency urinary incontinence (UUI) treated with tolterodine extended release (ER). Sexually active women with OAB symptoms were randomized to placebo or tolterodine ER. Five-day bladder diaries, Sexual Quality of Life Questionnaire—Female (SQOL-F), Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ), and Hospital Anxiety and Depression Scale (HAD) were completed at baseline and week 12. Tolterodine ER (n = 201; mean ± SD age, 49 ± 12 years) reduced UUI episodes (P = 0.0029), total (P = 0.0006) and OAB (P < 0.0001) micturitions, and pad use per 24 h (P = 0.0024), and was associated with improvements in SQOL-F (P = 0.004), PISQ total (P = 0.009), and HAD Anxiety (P = 0.03) scores versus placebo (n = 210; mean ± SD age, 47 ± 12 years). OAB symptoms improved with tolterodine ER as did the scores of sexual health and anxiety measures in sexually active women with OAB. |
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Keywords: | Anxiety Overactive bladder Sexual health Urgency urinary incontinence Women |
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