以野百合碱建立兔慢性肺动脉高压模型的效果分析

目的:探讨野百合碱(MCT)腹腔注射建立新西兰兔慢性肺动脉高压(CPH)模型的可行性。方法: 将84只新西兰兔随机分为两组，即对照组（24只）和模型组（60只）。在相同的饲料和饲养条件下，模型组腹腔注射MCT溶液60 mg/kg，对照组注射相同剂量的乙醇与生理盐水混合液，28 d后进行右心导管压力测定肺动脉的压力。结果: 右心导管各心腔压力的测定值显示，模型组肺的动脉收缩压、舒张压，右室收缩压、舒张压及右房收缩压、舒张压与对照组比较均呈升高的趋势，但仅右房舒张压的差异具有统计学意义（P<0.01）；模型组的平均肺动脉收缩压未达到30 mmHg，说明模型的制备不理想。病理检测的结果显示，与对照组比较，模型组兔肺小动脉血管的管壁增厚，平滑肌组织增殖明显。结论: MCT注射可致兔肺动脉血管平滑肌层增厚，造成血流动力学改变，但所致肺动脉压力升高的结果并不稳定，仍需进一步研究。

Analyses of monocrotaline-induced rabbit model of chronic pulmonary hypertension

AIM: To explore the feasibility of a rabbit model with chronic monocrotaline(MCT)-induced pulmonary hypertension.METHODS: Eighty-four New Zealand rabbits were randomly divided into two groups: control group of 24 rabbits and MCT group of 60 rabbits.The rats in both groups were given the same diet and were raised under the same conditions.Chronic pulmonary hypertension in the MCT group was developed by injection of MCT solution into the abdominal cavity,whereas only the same dosage of the mixed pure ethanol ...