急性冠状动脉综合征病变程度与血清骨保护素和脑钠尿肽水平有相关性

目的:探讨血清骨保护素(OPG)和脑钠尿肽(BNP)水平与急性冠状动脉综合征的关系。方法: 160例患者分为2组:急性冠脉综合征（ACS）90例，对照组70例；入院时检测血浆OPG和BNP水平并进行冠脉造影。根据造影结果将冠状动脉狭窄的数目分为1支，2支，3支病变组并分析其与冠脉病变Gensini评分的相关性。结果: 与对照组相比ACS患者OPG、BNP水平都较高，差异有统计学意义（P<0.01），且随病变支数的增加显著升高。OPG与冠脉病变Gensini评分间存在显著的相关性(r=0.61，P<0.01)；BNP与冠脉病变Gensini评分也有相关性(r=0.34，P<0.01)。多元回归分析发现OPG与BNP与冠心病发生独立相关（均P<0.01 ）。结论: 血清OPG、BNP水平的升高与ACS病变程度有关。

Relation between osteoprotegerin and B-type natriuretic peptide levels in patients with acute coronary syndrome

AIM: To analyze the relation between osteoprotegerin(OPG) and B-type natriuretic peptide(BNP) levels in patients with acute coronary syndrome(ACS).METHODS: One hundred and sixty consecutive patients were classified into two groups: acute coronary syndrome(ACS) and control group.OPG and BNP were measured upon hospital admission and compared in relation to the number of narrowed coronary vessels(1-,2-,3-vessel disease) and to the degree of stenoses according to Gensini score.RESULTS: Serum OPG and BNP levels ...