河南地区冠心病患者ApoB/apoA-I与颈动脉内膜中层厚度的关系

目的:分析河南地区冠心病患者血脂谱特征及载脂蛋白B(ApoB)/载脂蛋白A-I(ApoA-I)比值与颈动脉内膜中层厚度（cIMT）关系。方法: 冠脉造影确诊的正常对照组和冠心病患者，进行血脂及载脂蛋白生化分析，B型超声测量cIMT，统计学分析性别分组和ApoB/apoA-I比值分组血脂谱特征和cIMT的差异。多元回归分析cIMT和血脂谱的关系。结果: ①以性别分组的冠心病患者中，高密度脂蛋白胆固醇（HDL-C）、ApoA-I、ApoB/apoA-I、低密度脂蛋白胆固醇（LDL-C）/HDL-C、总胆固醇（TC）/HDL-C和cIMT在男女两组有显著差异（均P<0.05）。②以ApoB/apoA-I比值分组（男性截断点0.8，女性截断点0.7）的冠心病患者，年龄和他汀治疗率在ApoB/apoA-I比值低的男女两组均高于比值高的组（均P<0.05），糖尿病、吸烟、饮酒、cIMT和其他血脂谱指标在ApoB/apoA-I比值高的男女两组均高于比值低的组（均P<0.05）。③多元回归分析显示，仅ApoA-I、ApoB和ApoB/apoA-I回归系数有统计学差异（均P<0.05）。结论: 冠心病患者cIMT与ApoB/apoA-I比值显著相关。ApoB/apoA-I比值反映cIMT的敏感性比LDL-C更好。

Relationship between ApoB/apoA-I ratio and carotid artery intima-media thickness in patients with coronary heart disease in the Henan Region of China

AIM: To study the characteristics of lipid profile and the relationship between ApoB/apoA-I ratio and carotid artery intima-media thickness(cIMT) in patients with coronary heart disease(CHD) in the Henan Region of China in order to provide evidence for risk factor appraisal and efficiency of medical therapy.METHODS: Serum lipid and apolipoprotein of CHD patients confirmed by coronary angiography were biochemically analyzed.B-mode carotid ultrasonography of cIMT was performed in 812 patients.The differences ...