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Ellipticine and derivatives induce breakage of L1210 cells DNA in vitro.
Authors:C Paoletti  C Lesca  S Cros  C Malvy  C Auclair
Affiliation:Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS 205 route de Narbonne, 31078 Toulouse Cedex, France
Abstract:Part of the radioactive DNA extracted from prelabelled L1210 cells exposed in vitro to ellipticine, 9-hvdroxyellipticine, 2-methyl-9-hydroxyellipticinium and 9-aminoellipticine, migrate more slowly into an alkaline sucrose gradient. These effects occur in less than one hr of exposure, and can be detected at drug concentrations which lie respectively around 1000, 20, 100 and 500 ng per ml whereas the drug concentrations which inhibit by 50 per cent the rate of the in vitro cell growth are 242, 3.9, 13 and 53 ng per ml. The DNA breaks become rapidly undetectable when the cells' exposure to the drugs is discontinued.
Keywords:To whom reprint requests should be sent: 205 route de Narbonne   31078 Toulouse Cedex   France.
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