非酒精性脂肪性肝病与代谢综合征的相关性研究

目的分析非酒精性脂肪性肝病（NAFLD）与代谢综合征（MS）的关系。方法10357例在我院体检的普通人群入选本研究，检测人体学参数、生化指标及肝脏彩超，分析该人群NAFLD和MS的患病率，探讨MS组分与NAFLD的关系。结果10357例体检者中NAFLD的患病率为31．1％，MS患病率为23．6％，NAFLD合并MS患病率为15．5％。经年龄标化后NAFLD和MS患病率男性仍明显高于女性。将全部受试者按BM1分组后，各组间NAFLD、MS及NAFLD合并MS患病率差异均有统计学意义（P〈0．01）。选择同期体检无NAFLD的个体（非NAFLD组），经性别、年龄、BMI与NAFLD组相匹配后，NAFLD组MS患病率明显高于非NAFLD组（59．8％VS5．2％，P〈0．01）。多因素Logistic回归分析表明：NAFI。D危险因素的前五位为TG、BMI、FPG、LDL-C和吸烟。结论即使排除BMI因素的影响，NAFLD患者MS的患病率仍然明显增高。NAFLD危险因素由高到低依次为TG、BMI、FPG、LDL-C、吸烟、TC、性别、血压、SUA及ALT。HDL-C为NAFLD保护性因素。

Correlation between non-alcoholic fatty liver disease and metabolic syndrome

Objective To study the correlation of non-alcoholic fatty liver disease（NAFLD） and metabolic syndrome（MS）. Methods The anthroposomatology parameters, biochemical indicators and color Doppler ultrasound of liver were available to analyze the morbidity rate of NAFLD and MS in 10 357 adults receiving health examination and not suffering from excessive alcohol drinking, type B hepatitis and type C hepatitis in our hospital. All participants were divided into groups with different BMI to compare the morbidity difference of NAFLD and MS. In addition, after matching for gender, age and BMI in non- NAFLD group, correlation between MS and NAFLD was investigated. Results In 10 357 subjects receiving health examination, morbidity rate was 31. 1% for NAFLD ,23.6% for MS, and 15.5% for MS plus NAFLD. The morbidity rate of NAFLD and MS was higher in male than in female. Along with BMI increasing, the morbidity of NAFLD, MS, and NAFLD plus MS was increasing with statistical significance of their intergroup differences （P〈0.01）. The higher the BMI, the higher the morbidity rate of NAFLD was. In logistic regression analysis, the OR degrees from high to low for NAFLD were triglyeride, BMI, FPG, LDL-C and smoking. Conclusions The morbidity rate of MS in NAFLD group is higher. The OR degrees of NAFLD from high to low are triglyeride, BMI, FPG, LDL-C, smoking, TC, gender, blood pressure, SUA and ALT. HDL-C is a protective factor of NAFLD.