2型糖尿病肾病患者尿单核细胞趋化蛋白1和血细胞间黏附分子1与炎症反应的关系

目的 探讨糖尿病患者尿单核细胞趋化蛋白1（MCP-1）和血细胞间黏附分子1（ICAM-1）水平与糖尿病肾病的发生发展及炎症反应的关系。方法将90例糖尿病患者按尿白蛋白排泄率（UAER）分为正常白蛋白尿（NA）组、微量白蛋白尿（MA）组、临床白蛋白尿（CA）组，分别测定血、尿MCP-1与血sICAM-1和高敏C反应蛋白（hsC-RP），并与30名健康对照组（NC）比较。结果NC、NA、MA、CA组间的血MCP-1水平差异无统计学意义（P〉0．05），尿MCP-1及血sICAM-1水平逐渐升高，差异有统计学意义（P〈O．05或P〈0．01）；尿MCP-1及血sICAM-1水平与UAER均呈正相关（r=0．891，P〈0．01；r=0．583，P〈0．01）；尿MCp-1及血sICAM-1水平与血hsC-RP均呈正相关（r=0．723，P〈0．01；r=0．625，P〈0．01）。结论尿MCP-1及血slCAM-1水平与糖尿病肾病炎症反应程度有一定关系，可作为肾脏损害程度及其发生发展的判断指标。

Relationship of urine monocyte chemoattractant protein-1 and serum intercellular adhesion molecule-1 with inflammatory response in diabetic nephropathy of T2DM patients

Objective To study the correlation of monocyte chemoattractant protein-1 （MCP-1）and serum intercellular adhesion molecule-1 （sICAM-1） with inflammatory response in diabetic nephropathy of T2DM patients. Method 90 diabetes mellitus patients were divided into three subgroups （n = 30, each） ： normo-albuminuria （NA）, micro-albuminuria （MA） and clinical albuminuria （CA）. The MCP-1, sICAM-1 and hsC-RP were determined by ELISA respectively , which were compared with 30 normal controls （NC）. Results The levels of serum MCP-1 did not differ among groups of NC, NA, MA and CA （P〉0.05）. The levels of urine MCP-1 and serum sICAM-1 were progressively higher in CA group than in MA（P〈0.05 or P〈0.01）, in MA than in NA （P〈0.01）, and in NA than in NC （P（0. 01） The urine MCP-1 and serum sICAM-1 correlated positively with UAER （r=0. 891,P〈0. 01 ;r=0. 583, P%0. 01）and with serum hsC-RP （r=0. 723,P〈0.01;r=0. 625,P〈0. 01）. Conclusion The urine MCP-1 and serum sICAM-1 are associated with kidney damage and inflammatory response, and might serve as clues to potential predictors for the development of diabetic nephropathy.