2型糖尿病非增生型视网膜病变与颈动脉内膜中层厚度的关系

目的探讨2型糖尿病（T2DM）患者非增生型视网膜病变（NPDR）与颈动脉内膜中层厚度（IMT）之间的关系。方法选择NPDR组97例，糖尿病正常眼底（NDR）对组照100例。B超检测IMT。结果（1）NPDR组IMT明显高于NDR组（P〈0．01）。（2）NPDR与年龄、病程、收缩压、舒张压、糖化血红蛋白、IMT、尿白蛋白呈正相关（P〈0.05），与HDL-C、餐后2hC肽呈负相关（P〈0．05）。Logistic回归显示IMT是NPDR的主要危险因素（P〈0.01）。（3）IMT增厚组（60．7G）NPDR发病率明显高于正常组（44．1％）（P〈0.05）。结论T2DM合并颈动脉IMT增厚者NPDR发病率显著增高，推测动脉粥样硬化可能是NPDR的一个重要的相关因素。

Relationship between non-proliferative diabetic retinopathy and the carotid artery intima-media thickness in type 2 diabetic patients

Objective To explore the relationship between non-proliferative diabetic retinopathy and the carotid artery intima-media thickness（IMT） in type 2 diabetic patients. Methods 197 patients with type 2 diabetes mellitus were divided into two groups, 97 patients with non-proliferative diabetic retinopathy （NPDR） and 100 patients without diabetic retinopthy （NDR）. Intima-media thickness was measured using B mode ultrasonography. Results （ 1 ） IMT was significantly higher in patients with NPDR than in patients without DR（ P〈0. 01） ; （2）NPDR was positively correlated with age, the course of disease, systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin, IMT, urinary microalbumin （P〈0.05） and was negatively correlated with high density lipoprotein-cholesterol, 2h C- Peptide（P〈0.05）. Logistic regression analysis showed that IMT was the most important risk factor for NPDR （P〈0. 01）;（3）In diabetic patients, the prevalence of diabetic retinopathy was higher in thickened IMT group（60.7%） than in normal IMT group（44.1%） （P〈0.05）. Conclusions The morbidity of NPDR is higher in type 2 diabetic patients complicated with thickened IMT, speculating that atherosclerosis may be a critical relative factor of NPDR.