中国人群PAI-1基因40／50多态性与2型糖尿病肾病关系的Meta分析

目的评价中国人群纤溶酶原激活物抑制因子-1（PAI-1）基因4G／SG多态性与2型糖尿病肾病（T2DN）的关系。方法全面检索中国人群T2DN与PAI-1基因4G／5G多态性的病例对照研究，用Meta分析方法对PAI-1基因型分布和等位基因频率进行分析和比较，计算比值比（0R值）。结果共纳入9项符合条件的病例对照研究，Meta分析结果显示T2DN组较2型糖尿病非肾病（T2DM）组，4G／4G、4G／5G基因型及4G、5G等位基因合并OR值分别为3．01、0．61、1．95、0．51（P〈0．05）；T2DN组较正常对照（NC）组，4G／4G、4G／5G基因型及4G、5G等位基因合并OR值分别为2．96、0．70、2．34、0．41（P〈0．05）；T2DM组较NC组PAI-1基因4G／5G多态性各基因型及等位基因合并QR值无统计学差异（P〉0．05）。结论中国人群PAI-1基因4G／SG多态性与T2DN关系密切，4G／4G基因型及4G等位基因是T2DM人群及正常人群患T2DN的危险因素，4G／5G基因型及5G等位基因是患T2DN的保护性因素。

Meta analysis of association of PAI-1 4G/5G polymorphism with type 2 diabetic nephropathy in Chinese population

Objective To evaluate the association of PAI-1 4G/5G polymorphism with type 2 diabetic nephropathy （T2DM） in Chinese population. Methods All related case-control studies on the 4G/SG polymorphism in PAI-1 gene and DN were searched. PAI-1 genotype and allele frequency distribution were analyzed and compared through Meta-analysis, and the relative odds ratios（OR） were calculated. Results 9 case-control studies were retrived based on the criteria. Meta analysis results showed the pooled ORs of genotype 4G/4G,4G/SG and allele 4G, 5G of T2DN vs T2DM were 3.01,0. 61,1.95, 0. 51, respectively（P〈0. 05）. The pooled ORs of genotype 4G/4G, 4G/5G and allele 4G, 5G of T2DN vs NC were 2. 96,0. 70,2. 34,0.41, respectively（P〈0. 05）. The pooled ORs of PAI-1 genotype and allele of T2DM vs NC had no significant differences （P〉 0. 05）. Conclusion PAI-1 gene polymorphism is associated with T2DN in Chinese population. 4G/4G genotype and 4G allele are the risk factor for T2DN, and 4G/5G genotype and 5G allele are the protective factor for T2DN.