Primary thrombophilia in Mexico: A prospective study |
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Authors: | Guillermo J. Ruiz-Argü elles,Sonia Gonzá lez-Estrada,Javier Garcé s-Eisele,Alejandro Ruiz-Argü elles |
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Abstract: | A group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied. Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation. Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency. No cases of abnormalities in antithrombin III, plasminogen, tissue-type plasminogen activator or plasminogen activator inhibitor were found. The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy. Am. J. Hematol. 60:1–5, 1999. © 1999 Wiley-Liss, Inc. |
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Keywords: | thrombophilia thrombosis protein C protein S protein C resistance factor V Leiden Mexico |
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