Effect of orally administered heat-killed Enterococcus faecalis FK-23 preparation on neutropenia in dogs treated with cyclophosphamide |
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| Affiliation: | 1. School of Medical Sciences and Griffith Health Research Institute, Griffith University, Gold Coast campus, Southport, Queensland 4222, Australia;2. 98 Alive Pty Ltd., PO Box 82, Underwood, QLD 4119, Australia;3. National Defense Medical Center, Taipei, Taiwan;1. Plant Pathology Research Institute, Agricultural Research Center (ARC), Giza, Egypt;2. Research Central Laboratory, SAGO, Riyadh, Saudi Arabia;3. CIHEAM IAMB, Mediterranean Agronomic Institute of Bari, Bari, Italy;4. Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia;1. Department of Food Science and Engineering, Harbin Institute of Technology, No. 73 Huanghe Road, Harbin 150090, China;2. The First Affiliated-Hospital of Harbin Medical University, No. 157 Baojian Road, Harbin 150086, China |
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| Abstract: | Dogs injected intravenously for 3 days with cyclophosphamide (CY) at a dose of 10 mg/kg were given 100 mg/kg of Enterococcus faecalis FK-23 preparation (FK-23) perorally for 14 days to confirm the beneficial effects of the latter drug in neutropenic dogs when orally administered. Although FK-23 treatment did not inhibit CY-induced neutropenia, it augmented neutrophil-reconstituting capacity in these dogs. Increases in the myeloid/ erythroid ratio and neutrophilic lineages were found in the bone marrow of FK-23 administered dogs. The oral administration significantly restored the reduced activity of neutrophil phagocytosis and chemiluminescence in dogs treated with CY. These findings indicate that FK-23 administered perorally not only augments neutrophil reconstitution through the activation of bone marrow but also functions in dogs treated with CY. It may thus be a useful supportive agent to reduce the adverse side-effects associated with the administration of chemotherapeutic agents such as CY. |
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