| 消癥注射液对大鼠子宫内膜异位囊肿的治疗机理初探 |
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| 引用本文： | 王桂萍,萧美茹,王素改. 消癥注射液对大鼠子宫内膜异位囊肿的治疗机理初探[J]. 辽宁中医杂志, 2008, 35(4): 611-613 |
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| 作者姓名： | 王桂萍 萧美茹 王素改 |
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| 作者单位： | 1. 天津市中医药研究院妇科,天津,300120
2. 天津中医药大学,天津,300193 |
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| 基金项目： | 国家中医药管理局科研项目 |
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| 摘 要： | 目的:探讨消癥注射液治疗子宫内膜异位症的作用机制。方法:采用大鼠自体子宫内膜移植术建立实验性子宫内膜异位囊肿模型,采用囊肿腔内注射给药方式,分别观察消癥注射液和无水酒精对模型鼠外周血清、在位内膜组织、异位内膜组织血管内皮生长因子(VEGF)表达的影响。结果:消癥注射液对上述组织中VEGF均有不同的下调或抑制作用,与模型组相比有显著性差异(P<0.05),消癥注射液高浓度组、低浓度组与无水酒精相比无显著性差异(P>0.05),但是消癥注射液低浓度组几组数值更接近正常组,以它效果最好。结论:消癥注射液对实验性异位症有显著的治疗效果,其中抗血管生成可能是其作用机理之一。
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| 关 键 词： | 子宫内膜异位症 消癥注射液 血管内皮生长因子 血清 实验研究 |
| 文章编号： | 1000-1719(2008)04-0611-03 |
| 修稿时间： | 2007-11-12 |
Exploration OD the Mechanism of Xiao Zheng Injection on Endometriosis of Rat Model |
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| WANG Gui-ping,XIAO Mei-ru,WANG Su-gai. Exploration OD the Mechanism of Xiao Zheng Injection on Endometriosis of Rat Model[J]. Liaoning Journal of Traditional Chinese Medicine, 2008, 35(4): 611-613 |
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| Authors: | WANG Gui-ping XIAO Mei-ru WANG Su-gai |
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| Abstract: | Objective:Study of mechanism of Xiao Zheng Injection on endometriosis of rat model.Methold:The rat model of endometriosis was made by implanting its endometrium into peritoneum;compared the morphologic change after given treatment;Detected the VEGF in serum by ELISA;Detected the protein VEGFexpression in eutopic and ectopic endometrium.Result:Xiao Zheng injection can decease the expression of VEGF in serum,eutopic and ectopic endometrium,contrast to model group,P<0.05,among three treating group,the effect of lower density of Xiao Zheng injection is the best.Conclusion:There is a good result of Xiao Zheng injection to endometriosis,maybe anti-angiogenesis is one of the mechanism of it. |
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| Keywords: | endometriosis Xiao Zheng injection VEGF serum experiment study |
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