慈仁胶囊治疗Ⅲ_b、Ⅳ期非小细胞肺癌近期疗效观察

目的:观察慈仁胶囊治疗Ⅲb、Ⅳ期非小细胞肺癌的近期疗效。方法:60例符合标准的Ⅲb、Ⅳ期非小细胞肺癌患者随机分为治疗组和对照组,分别服慈仁胶囊和接受NP方案即NVB(诺维本)+DDP(顺铂)]化疗4周期。测定两组治疗前和治疗后实体瘤疗效、症状积分、免疫状况、生存质量和不良反应等指标。结果:治疗组的瘤体缓解总有效率(CR+PR)为0,对照组为26.7%,有显著性差异(P<0.05);治疗组病灶稳定率为(CR+PR+SD)为86.7%,对照组的病灶稳定率为80%,无显著性差异(P>0.05)。治疗组和对照组均可改善症状,但前者明显优于后者(P<0.01)。治疗后治疗组CD3+、CD4+和NK细胞升高,对照组的CD3+和CD4+降低。治疗后两组的体质量和体力状况评分变化均无显著性差异(P>0.05),生活质量评分均升高,但治疗组优于对照组,有显著性差异(P<0.05)。治疗组没有发生不良反应,对照组白细胞减少发生率为53.3%,恶心呕吐发生率为66.7%,肝功能损害发生率为20%,偶见脱发、神经系统损害等不良反应。结论:慈仁胶囊治疗Ⅲb、Ⅳ期非小细胞肺癌,可稳定瘤体,有效改善肺癌症状和提高生活质量,提高机体细胞免疫力,无明显不良反应。

Observasion of immediate effectiveness of Ciren capsulein treating advanced NSCLC

Objective: To evaluate the effectiveness and safety of Ciren capsule in the treatment of advanced NSCLC.Methods: A total of 60 eligible patients with advanced NSCLC were randomly assigned to treatment group and control group.30 patients in treatment group took Ciren capsule for 4 cycles.30 patients in control group accepted NP regimens for 4~6 cycles.The effectiveness and safety of both treatment were estimated.Results: The response rates(CR+PR)were 0 and 26.7% in the treatment group and control group,significant difference was detected among them(P<0.05).The stable rates(CR+PR+SD)were 86.7% and 80% in the treatment group and control group,no significant difference was detected among them(P>0.05).Both the chemotherapy and Ciren capsule relieved symptom and improved the quality of life,but the former was significantly better than the latter.In the treatment group,the count of CD3~+、CD4~+ and NK cell was higher than that of pre-treatment.In the control group,the count of CD3~+、(CD4~+) lowered after chemotherapy(P<0.05).No toxicities were observed in Ciren capsule.In the control group,leukocytopenia incidence is 53.3%,vomiting incidence 66.7%,hepatic function lesion incidence 20%,still alopecia and neurologic toxicities occurred.Conclusion: Ciren capsule in the treatment of advanced NSCLC contribute to stabilizing the neoplasia,relief of symptom,improvement of the quality of life and enhancement of the immunity.Also it proved to be safe.