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Discovery of a Highly Potent,Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors |
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| Authors: | Jin-Jun Liu Brian Higgins Grace Ju Kenneth Kolinsky Kin-Chun Luk Kathryn Packman Giacomo Pizzolato Yi Ren Kshitij Thakkar Christian Tovar Zhuming Zhang Peter M. Wovkulich | |
| Affiliation: | †Discovery Chemistry, ‡Discovery Oncology, and §Chemical Synthesis, Hoffmann-LaRoche Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States | |
| Abstract: | ||
| Keywords: | pyrazolobenzodiazepines, mitosis/angiogenesis inhibitor, antitumor effect, VGFr-2, FGFr and PDGFr-β | |