Leisure-time physical activity and mortality risk in type 2 diabetes: A nationwide cohort study |
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| Affiliation: | 1. Section of Infectious Diseases, Taipei City Hospital, Taipei City Government, Taipei, Taiwan;2. Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan;3. Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan;4. Division of Chest Medicine, Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Nantou, Taiwan;5. Department of Eldercare, Central Taiwan University of Science and Technology, Taichung, Taiwan;6. School of Medicine, National Yang-Ming University, Taipei, Taiwan;7. Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan;8. School of Medicine, Chung Shan Medical University, Taichung, Taiwan;9. College of Public Health, National Taiwan University, Taipei, Taiwan;10. Department of Anaesthesiology, Chi Mei medical center, Tainan, Taiwan;11. Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan;12. Graduate Institute of Sports and Health Management, National Chung Hsing University, Taichung, Taiwan;13. Division of Endocrinology and Metabolism, Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Nantou, Taiwan |
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| Abstract: | AimPhysical activity improves insulin resistance, inhibits inflammation, and decreases the incidence of cardiovascular disease. These are major causes of death in patients with diabetes.MethodsThe Taiwan National Health Interview Survey collected baseline characteristics of socioeconomic level, education, marriage, and health behaviour, including leisure time physical activity in 2001, 2005, 2009, and 2013. The National Health Insurance research dataset 2000–2016 contained detailed information on medical conditions, including all comorbidities. All-cause and cardiovascular deaths were confirmed by the National Death Registry.ResultsA total of 4859 adults with type 2 diabetes were included in the analysis; 2389 (49 %) were men and the mean±SD age was 60±13 years. Kaplan-Meier curve of all-cause (log-rank P<0.001) and cardiovascular death (log-rank P=0.038) categorized by leisure-time physical activity showed a significant difference. The multivariable Cox regression model showed that those who had more leisure time physical activity had a significantly lower risk of all-cause death than those with no physical activity (physical activity of 1-800 MET-min/week HR = 0.66, 95% CI: 0.54–0.81, physical activity of >800 MET-min/week HR = 0.67, 95% CI: 0.56-0.81). A significant trend was also observed (P <0.001). Similar results were also observed for cardiovascular mortality (physical activity of 1-800 MET-min/week HR = 0.54, 95% CI: 0.36–0.84, physical activity of >800 MET-min/week HR = 0.78, 95% CI: 0.55–1.13).ConclusionFor those with diabetes, increased leisure-time physical activity significantly reduced risk of all-cause and cardiovascular death. Further research is warranted to determine the proper prescription for physical activity to prolong healthy life. |
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