In-vivo anti-inflammatory and anti-pyretic activities of Manilkara zapota leaves in albino Wistar rats |
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Authors: | Amlan Ganguly Zobaer Al Mahmud Mir Muhammad Nasir Uddin SM Abdur Rahman |
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Institution: | 1.Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh;2.Department of Pharmacy, North South University, Basundhara, Baridhara, Dhaka-1229, Bangladesh;Professor, Department of Pharmaceutical Chemistry, University of Dhaka, Bangladesh., Tel: +88-2-9677623 (office) +88-01711972965 (cell) E-mail: |
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Abstract: | ObjectiveTo screen ethanolic extracts of Manilkara zapota leaves (Family: Sapotaceae) and its different solvent soluble fractions for possible anti-inflammatory, anti-pyretic activities in experimental albino Wistar rats.MethodsAnti-inflammatory activity was evaluated by carrageenan induced paw edema method; anti-pyretic potential was determined by yeast-induced pyrexia method in albino Wistar rats.ResultsIn evaluation of anti-inflammatory activity the crude ethanolic (300 mg/kg) and ethyl acetate extract (300 mg/kg) showed significant inhibition of paw edema by 91.98% and 92.41% (P<0.001) respectively at 4th h compared to standard diclofenac (86.08% inhibition). In anti-pyretic study by yeast-induced pyrexia in albino Wistar rats, the ethanol extract (300 mg/kg) reduced temperature from 37.90 °C to 37.41 °C (P<0.01) and 37.07 °C (P<0.001) in 3rd and 4th h respectively. Similarly, both petroleum ether and ethyl acetate fractions exhibited significant anti-pyretic property (P<0.001). The maximum body temperature lowering effect (36.86 °C) was noticed by petroleum ether fraction.ConclusionsThe findings of the studies demonstrated both anti-inflammatory and anti-pyretic activities of the leaves of Manilkara zapota which could be the therapeutic option against inflammatory disease and pyrexia. |
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Keywords: | Manilkara zapota Carrageenan Paw edema Yeast-induced pyresis |
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