Sedation level with midazolam: A pediatric surgery approach |
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| Authors: | Carmen Flores-Pé rez,Luis Alfonso Moreno-Rocha,Juan Luis Chá vez-Pacheco,Norma Angé lica Noguez-Mé ndez,Janett Flores-Pé rez,Marí a Fernanda Alcá ntara-Morales,Luz Corté s-Vá squez,Lina Sarmiento-Argü ello |
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| Affiliation: | 1. Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), Ciudad de México, México;2. Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana (UAM), Ciudad de México, México;3. Laboratorio de Farmacocinética y Farmacodinamia, UAM Xochimilco, Ciudad de México, México;4. Laboratorio de Farmacia Molecular y de Liberación Controlada, UAM Xochimilco, Ciudad de México, México;5. Departamento de Anestesiología, INP, Ciudad de México, México |
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| Abstract: | Midazolam (MDZ) is a short-acting benzodiazepine that is widely used to induce and maintain general anesthesia during diagnostic and therapeutic procedures in pediatric patients due to its sedative properties. The aim of this study was to perform a systematic review without a meta-analysis to identify scientific articles and clinical assays concerning MDZ-induced sedation for a pediatric surgery approach. One hundred and twenty-eight results were obtained. After critical reading, 37 articles were eliminated, yielding 91 publications. Additional items were identified, and the final review was performed with a total of 106 publications.In conclusion, to use MDZ accurately, individual patient characteristics, the base disease state, comorbidities, the treatment burden and other drugs with possible pharmacological interactions or adverse reactions must be considered to avoid direct alterations in the pharmacokinetics and pharmacodynamics of MDZ to obtain the desired effects and avoid overdosing in the pediatric population. |
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| Keywords: | Midazolam Pharmacokinetics-pharmacodynamics Pharmacological interactions Adverse reactions Pediatrics Sedation MDZ" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" Midazolam Vd" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" Distribution volume CL" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" Clearance Elimination half-life PopPK" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" Population pharmacokinetics NONMEM" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" Nonlinear mixed effects modeling GABA" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" Gamma-aminobutyric acid BIS" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," _" :" Bispectral index EEG" },{" #name" :" keyword" ," $" :{" id" :" k0120" }," $$" :[{" #name" :" text" ," _" :" Electroencephalogram CNS" },{" #name" :" keyword" ," $" :{" id" :" k0130" }," $$" :[{" #name" :" text" ," _" :" Central nervous system |
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