Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| |
Authors: | Naiju Zhang Fan Zhang Zhong Chen Rui Huang Juan Xia Jinchun Liu |
| |
Affiliation: | 1. Department of Pharmacy, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Key Laboratory of Immunology in Chronic Diseases, The first Affiliated Hospital of Bengbu Medical College, Anhui, Bengbu, China;2. Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, Nanjing 210008, PR China;3. Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Medical Center for Clinical Pharmacy, Jiangsu, Nanjing 210008, PR China |
| |
Abstract: | Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ dysfunction and mortality. This case report describes the development of lactic acidosis in a 64-year-old Chinese woman who had received 33 days of treatment with antituberculosis drugs and 28 days of treatment with oral linezolid for tuberculous meningitis. Severe lactic acidosis was reversed by withdrawing antituberculosis drugs and using continuous venovenous hemodiafiltration (CVVH). When the patient's condition was stable, she was transferred to the infectious disease department, and antituberculosis drugs, with the exception of linezolid, were reintroduced. This did not result in recurrence of lactic acidosis. The causal relationship between lactic acidosis and linezolid was categorized as ‘probable’ on the Adverse Drug Reaction Probability Scale. This case demonstrates that CVVH has potential as an alternative to discontinuation of linezolid alone for rapid reversal of linezolid-associated severe lactic acidosis. |
| |
Keywords: | Linezolid Lactic acidosis CVVH Case report CVVH" },{" #name" :" keyword" ," $" :{" id" :" pc_hvPuS3A2NB" }," $$" :[{" #name" :" text" ," _" :" continuous venovenous hemodiafiltration arterial partial pressure of oxygen arterial partial pressure of carbon dioxide PT" },{" #name" :" keyword" ," $" :{" id" :" pc_Uzw0kZHvy4" }," $$" :[{" #name" :" text" ," _" :" prothrombin time APTT" },{" #name" :" keyword" ," $" :{" id" :" pc_BLx8skX0GA" }," $$" :[{" #name" :" text" ," _" :" activated partial thromboplastin time TT" },{" #name" :" keyword" ," $" :{" id" :" pc_WnVoc5UqE7" }," $$" :[{" #name" :" text" ," _" :" thrombin time FIB" },{" #name" :" keyword" ," $" :{" id" :" pc_zcvoh9cie1" }," $$" :[{" #name" :" text" ," _" :" fibrinogen ICU" },{" #name" :" keyword" ," $" :{" id" :" pc_SbPitnTtpF" }," $$" :[{" #name" :" text" ," _" :" intensive care unit CRRT" },{" #name" :" keyword" ," $" :{" id" :" pc_KGbBvaOE9z" }," $$" :[{" #name" :" text" ," _" :" continuous renal replacement therapy ADR" },{" #name" :" keyword" ," $" :{" id" :" pc_3ahi66NOPm" }," $$" :[{" #name" :" text" ," _" :" Adverse Drug Reaction ESRD" },{" #name" :" keyword" ," $" :{" id" :" pc_PvRLJmPHMH" }," $$" :[{" #name" :" text" ," _" :" end-stage renal disease |
本文献已被 ScienceDirect 等数据库收录! |
|