Association of spondyloarthritis and sarcoidosis: A retrospective observational population-based matched cohort study |
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| Affiliation: | 1. Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, 28922 Madrid, Spain;2. Department of Preventive Medicine and Public Health, Universidad Rey Juan Carlos, Madrid, Spain;3. Department of Diagnostic Imaging, Hospital Vithas Nuestra Señora de América, Madrid, Spain;4. Centro de Salud La Rivota (Alcorcón), 29922 Madrid, Spain;5. Department of Clinical Research, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain;6. Department of Rheumatology, Hospital Universitario La Princesa, 28006 Madrid, Spain;1. Department of Rheumatology, St James’ Hospital, James’ Street, Dublin 8, Ireland;2. School of Medicine, Trinity College, Dublin, Ireland;3. Department of Rheumatology, St Vincent''s Hospital, Dublin, Ireland;1. ENT department, Charles-Nicolle Hospital, Boulevard du 9-Avril 1938, 1006 Tunis, Tunisia;2. Faculty of medicine of Tunis, University Tunis-el-Manar, Tunis, Tunisia;1. Department of Rheumatology, CHRU de Besançon, 3, boulevard Fleming, 25000 Besançon, France;2. EA 4267 “PEPITE”, UFR Santé, Franche-Comté University, 19, rue Ambroise Paré, bâtiment S, 25030 Besançon cedex, France;3. EA 4266 « EPILAB », UFR Santé, Franche-Comté University, 19, rue Ambroise Paré, bâtiment S, 25030 Besançon cedex, France;1. Université de Tours, Tours, France;2. Service de rhumatologie, CHRU de Tours, 37044 Tours cedex, France;3. Service de médecine intensive réanimation, CHRU de Tours, Tours, France;4. Service de médecine interne, CHRU de Tours, Tours, France;5. Service d’information médicale, d’épidémiologie et d’économie de la santé, CHRU de Tours, 37000 Tours, France;1. Department of infectious diseases, Avicenne Hospital, Bobigny, France;2. Department of rheumatology, Avicenne Hospital, Bobigny, France;3. Department of microbiology, Avicenne Hospital, Bobigny, France;1. Rheumatology Department, Nantes University Hospital, Hôtel-Dieu, Place Alexis-Ricordeau, 44093 Nantes Cedex 01, France;2. Rheumatology Department & Inserm UMR 1132 (centre Viggo Petersen), Hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, France;3. Université de Paris, UFR de Médecine, 75010 Paris, France;4. Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France;5. RESO: Centre de Référence des Maladies Autoimmunes Systémiques Rares Est Sud-Ouest, Strasbourg, France;6. INSERM UMR_S1109, Université de Strasbourg, 67000 Strasbourg, France |
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| Abstract: | ObjectivesTo investigate the association between spondyloarthritis (SpA) and sarcoidosis.MethodsAn observational retrospective population-based matched cohort study was conducted. Using data from the Spanish Minimum Basic Data Set. All the admissions of patients with SpA reported between 1999 and 2015 were analysed and a control group matched by age, sex and year of admission was selected. Crude and age- and sex-adjusted incidence rates for sarcoidosis were calculated. Generalized linear models were used for trend analysis and unconditional logistic regression models for calculating crude and adjusted odds ratios (ORs) to assess the association between sarcoidosis and SpA.ResultsThe study database contained data on 214,280 hospitalisations: 107,140 admissions of patients with SpA and 107,140 of patients without SpA. Overall, 220 of the admissions were of patients with sarcoidosis: 133 (0.12%) in the SpA group and 87 (0.08%) in the non-SpA group (P < 0.05). The incidence rates of sarcoidosis were 2.68 and 1.64 per 100,000 per year in the SpA and non-SpA groups, respectively. The trend was similar in the two cohorts. Regarding potential associations between SpA and sarcoidosis, the crude and adjusted ORs were 1.52 (95% CI: 1.16–2.01) and 1.50 (95% CI: 1.14–1.97) overall in patients with SpA, with adjusted ORs of 1.42 (95% CI: 1.03–1.94) and 1.81 (95% CI: 1.29–2.55) in patients with ankylosing spondylitis and psoriatic arthritis, respectively.ConclusionsThere is a relationship that is not due to chance between sarcoidosis and SpA and specifically that sarcoidosis is significantly associated with ankylosing spondylitis and psoriatic arthritis. |
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| Keywords: | Sarcoidosis Spondyloarthritis Association |
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