Platelet transfusion practice and related transfusion reactions in a large teaching hospital |
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Affiliation: | 1. Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Ki?pati?eva 12, 10000 Zagreb, Croatia;2. University of Applied Health Sciences, Zagreb, Croatia;3. School of Medicine, University of Zagreb, Croatia;4. Department of Health Studies, University of Split, Croatia |
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Abstract: | BackgroundPlatelet transfusion practice varies widely since many aspects of platelet concentrate (PC) use have not been definitively determined. The objectives of this retrospective study were to present platelet transfusion practice and evaluate PC and patient characteristics, as well as their association with transfusion reaction (TR) rate.Material and methodsPlatelet transfusions over a 5-year period were analysed regarding PC characteristics (the ABO and RhD compatibility, product type, and storage duration), patient characteristics (most responsible diagnosis, age, and gender), and TR type.ResultsA total of 46,351 PCs were transfused: 76.4% whole blood-derived (WBD) and 23.6% single donor apheresis (SDA). Three thousand seven hundred seventy-six patients received platelet transfusions: 24.7% paediatric and 75.3% adult patients, 79.6% outpatients and 20.4% inpatients. As much as 63.1% of all transfused PCs were fresh (stored for ≤ 3 days), 98.0% ABO-identical, and 87.3% of all PCs given to RhD? patients were RhD?. PCs were mainly transfused to haemato-oncology (76.8%) and cardiovascular surgery patients (6.5%). Overall, 84 (0.18%) TRs were reported, with allergic TRs (ATRs) being the most common. Although PC ABO compatibility and storage duration, as well as patient age and gender, showed differences in TR rate, only the use of PCs in platelet additive solution (PAS) showed a statistically significant reduction of TRs (P < 0.001).ConclusionTransfusion practice at the University Hospital Centre Zagreb resulted in almost all patients receiving ABO and RhD identical PCs, and most of them were fresh PCs. The most important factor affecting the incidence of TRs was platelet storage solution. The use of PAS effectively reduced the rate of TRs, particularly allergic TRs. |
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Keywords: | Platelet transfusion Platelet concentrates ABO non-identical Transfusion reaction Transfusion de plaquette Concentrés de plaquettes ABO non identique Réaction transfusionnelle |
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