Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable
TGR5 Agonists |
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| Authors: | David W. Piotrowski,Kentaro Futatsugi,Joseph S. Warmus,Suvi T.
M. Orr,Kevin D. Freeman-Cook,Allyn T. Londregan,Liuqing Wei,Sandra M. Jennings,Michael Herr,Steven B. Coffey,Wenhua Jiao,Gregory Storer,David Hepworth,Jian Wang,Sophie Y. Lavergne,Janice E. Chin,John R. Hadcock,Martin
B. Brenner,Angela C. Wolford,Ann M. Janssen,Nicole S. Roush,Joanne Buxton,Terri Hinchey,Amit S. Kalgutkar,Raman Sharma,Declan A. Flynn |
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| Affiliation: | Pfizer Worldwide Researchand Development, Groton, Connecticut 06340, United States |
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| Abstract: | | |
| Keywords: | GPCR TGR5 agonist diabetes GLP-1 |
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