Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat. |
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Authors: | M Yanagisawa K Yoshioka T Kurihara K Saito N Seno H Suzuki R Hosoki M Otsuka |
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Affiliation: | Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan. |
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Abstract: | A mixture of peptidase inhibitors increased the magnitude of the saphenous nerve-evoked slow depolarization of a lumbar ventral root and prolonged the similarly evoked inhibition of monosynaptic reflex (MSR) in the isolated spinal cord of the newborn rat in the presence of naloxone. The saphenous nerve-evoked MSR inhibition was curtailed by a tachykinin antagonist, GR71251, and after the treatment with GR71251, the peptidase inhibitor mixture no more prolonged the MSR inhibition. The present results suggest that enzymatic degradation plays a role in the termination of action of tachykinins released from primary afferents in the newborn rat spinal cord. The results provide a further support for the notion that tachykinins serve as neurotransmitters in the spinal cord of the newborn rat. |
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