| HPLC法测定小儿清热止咳泡腾片及麻黄中盐酸麻黄碱的含量 |
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| 引用本文： | 常增荣,王萌萌,张小茜. HPLC法测定小儿清热止咳泡腾片及麻黄中盐酸麻黄碱的含量[J]. 中国药品标准, 2004, 5(2): 43-46 |
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| 作者姓名： | 常增荣 王萌萌 张小茜 |
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| 作者单位： | 北京市药品检验所,100035 |
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| 摘 要： | 目的:建立测定小儿清热止咳泡腾片中盐酸麻黄碱含量的方法.方法:采用HPLC法,以优选的乙腈-水-磷酸-三乙胺(3: 97 : 0.1 : 0.1)为流动相;检测波长为205nm,测定了小儿清热止咳泡腾片麻黄中盐酸麻黄碱的含量.结果:盐酸麻黄碱色谱峰峰形对称,且与杂质峰获得了完全分离,精密度、重现性及回收率实验等均符合要求,并用此方法考察了药材麻黄中盐酸麻黄碱含量.结论:方法准确性好、操作简便,可用于盐酸麻黄碱的含量控制.
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| 关 键 词： | 高效液相色谱法 盐酸麻黄碱 小儿清热止咳泡腾片 麻黄 |
Determination of Ephedrine in Xiaoer Qingre Zhike Effervescent Tablets and Hebra Ephedrae by HPLC |
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| Chang Zengrong,Wang Mengmeng and Zhang Xiaoqian. Determination of Ephedrine in Xiaoer Qingre Zhike Effervescent Tablets and Hebra Ephedrae by HPLC[J]. , 2004, 5(2): 43-46 |
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| Authors: | Chang Zengrong Wang Mengmeng Zhang Xiaoqian |
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| Affiliation: | Beijing institute for drug control, Beijing 100035;Beijing institute for drug control, Beijing 100035;Beijing institute for drug control, Beijing 100035 |
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| Abstract: | Objective:To develop a method to determine the content of Ephedrine in Xiaoer Qingre Zhike effervescent tablets and Hebra Ephedrae. Methods:HPLC method was used. The separation was performed on C18 colum with acetonitrile-water -phosphoric acid-triethylamine(3:97:0. 1:0. Das a mobile phase and the wavelength of uv detector was 205nm. Results: The method shows good resolution. Conclusion:The method is simple,reliable. It can be used in quality control of Ephedrine. |
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| Keywords: | Ephedrine Xiaoer Qingre Zhike Efferverscent Tablets Hebra Ephedrae HPLC |
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