| 茵陈蒿汤保肝作用的机理—对小鼠腹腔巨噬细胞释放TNF的影响 |
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| 引用本文： | 洪敏,朱荃,等.茵陈蒿汤保肝作用的机理—对小鼠腹腔巨噬细胞释放TNF的影响[J].中药药理与临床,1999,15(1):3-6. |
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| 作者姓名： | 洪敏 朱荃 |
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| 作者单位： | 南京中医药大学药理毒理实验室 |
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| 摘 要： | 目的：探讨茵陈蒿汤醇提物的保肝作用与肿瘤坏死因子（ＴＮＦ）的关系。方法：ＴＮＦ以ＭＴＴ法检测。结果：茵陈蒿汤醇提物０２～２０μｇ直接加入小鼠腹腔巨噬细胞培养液可抑制ＴＮＦ的释放；血清药理学表明含茵陈蒿汤醇提物小鼠血清１００、１５０、２００、２５０ｍｉｎ对ＴＮＦ也有抑制作用，且有时效关系，效应高峰在２００ｍｉｎ。结论：茵陈蒿汤醇提物保肝途径之一是调节巨噬细胞释放ＴＮＦ的功能
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| 关 键 词： | 茵陈蒿汤 巨噬细胞 TNF 血清药理学 |
Antihepatotoxic Mechanism of Alcohol Extract of Capillaris Decoction Effect on LPS induced release of TNF from mouse peritoneal macrophage in vitro |
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| Hong Min,Zhu Quan,Sun Xiaoyu.Antihepatotoxic Mechanism of Alcohol Extract of Capillaris Decoction Effect on LPS induced release of TNF from mouse peritoneal macrophage in vitro[J].Pharmacology and Clinics of Chinese Materia Medica,1999,15(1):3-6. |
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| Authors: | Hong Min Zhu Quan Sun Xiaoyu |
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| Abstract: | The TNF synthesis and secretion from mouse peritoneal macrophages in vitro were reduced markedly by alcohol extract of Capillaris Decoction.The serum,took out from the mice which treated with alcohol extract of Capillaris Decoction,also inhibited TNF release from mouse peritoneal macrophages.This suggested inhibition of TNF are among ways through which alcohol extract of Capillaris Decoction protect mice from experimental liver injury. |
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| Keywords: | Alcohol extract of Capillaris Decoction TNF macrophages |
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