Stereochemistry of pladienolide B |
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| Authors: | Asai Naoki Kotake Yoshihiko Niijima Jun Fukuda Yoshio Uehara Taisuke Sakai Takashi |
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| Institution: | Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan. n2-asai@hhc.eisai.co.jp |
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| Abstract: | Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products. |
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