Dissociation of Tc-99m DTPA in a nebulizer |
| |
Authors: | Hinton Paul J Clauss Ralf P |
| |
Affiliation: | Department of Medical Physics, Royal Surrey County Hospital, Guildford, Surrey, UK. paul.hinton@nhs.net |
| |
Abstract: | An unexpected biodistribution of nebulized Tc-99m diethylene triamine pentaacetic acid was detected after the ventilation of a patient referred for diagnosis of pulmonary embolism. Radiochemical purity testing of the stock vial showed more than 95% labelling. Further investigation indicated that the problem was possibly associated with a cleaning agent used for the nebulizer, leading to the dissociation of the Tc-99m diethylene triamine pentaacetic acid. Manufacturer's instructions for cleaning of the nebulizer specify the use of 70% denatured ethanol solution, but a chlorine-based agent had been used inadvertently. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|