Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia |
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Authors: | Wallingford John B Mitchell Brian |
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Affiliation: | Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA. wallingford@mail.utexas.edu |
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Abstract: | Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia. |
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Keywords: | cilia Wnt signaling planar cell polarity basal bodies diffusion barriers ciliary pores IFT |
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