Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death |
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| Authors: | Mukesh Kumar Saguna Verma Vivek R Nerurkar |
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| Institution: | 1.Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine,University of Hawaii at Manoa,Honolulu,USA |
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| Abstract: | Background WNV-associated encephalitis (WNVE) is characterized by increased production of pro-inflammatory mediators, glial cells activation
and eventual loss of neurons. WNV infection of neurons is rapidly progressive and destructive whereas infection of non-neuronal
brain cells is limited. However, the role of neurons and pathological consequences of pro-inflammatory cytokines released
as a result of WNV infection is unclear. Therefore, the objective of this study was to examine the role of key cytokines secreted
by WNV-infected neurons in mediating neuroinflammatory markers and neuronal death. |
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