Drug-Induced Antibodies: Interaction of the Drug with a Polymorphic Platelet-Antigen |
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| Authors: | Frans H J Claas Janneke Langerak Lois Lolkes de Beer Jon J van Rood |
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| Institution: | Department of Immunohematology, University Medical Center, Leiden, The Netherlands |
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| Abstract: | Preincubation of donor platelets with ticarcillin will prevent the reactivity of a platelet antibody against these platelets, whereas no influence was observed on antisera against HLA, 5A, 5b and ZWa. The implications for the mechanism of drug-induced antibodies with restricted specificity will be discussed. |
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