Effects of nifedipine on isolated human pulmonary vessels |
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| Authors: | M Sakr E Mikkelsen |
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| Affiliation: | 1. Department of Family and Community Medicine, University of Texas Medical School at Houston, 6431 Fannin Street, JJL 324, Houston, TX 77030, USA;2. Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, 1941 East Road, Houston, TX 77054, USA;3. Department of Pediatrics, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 3.020, Houston, TX 77030, USA;4. University of Texas Health Science Center at San Antonio, Department of Psychiatry, Mail Code 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA;5. McLean Hospital, Division of Alcohol and Drug Abuse & Harvard Medical School, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478, USA;6. University of Texas Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd., Dallas, TX 75390-9119, USA |
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| Abstract: | The effects of the Ca-blocker nifedipine on the contractile response to K and NA in isolated human pulmonary vessels were studied. Specimens of macroscopically normal pulmonary vessels, obtained from patients undergoing surgery for lungtumours were carefully dissected and cut into rings. The results suggest that nifedipine, by blocking the entry of extracellular calcium, inhibits K-induced contractions in isolated pulmonary vessels. The effect is more pronounced on K than on NA-induced response in both the pulmonary arteries and veins. |
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