| 海水浸泡对失血性休克大鼠肠粘膜上皮细胞线粒体功能的影响 |
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| 引用本文： | 伊远学,陆松敏,刘建仓,史成和,李萍. 海水浸泡对失血性休克大鼠肠粘膜上皮细胞线粒体功能的影响[J]. 第三军医大学学报, 2003, 25(16): 1454-1455 |
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| 作者姓名： | 伊远学 陆松敏 刘建仓 史成和 李萍 |
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| 作者单位： | 第三军医大学附属大坪医院野战外科研究所第二研究室,重庆,400042 |
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| 基金项目： | 全军“十五”指令性课题 ( 0 1L0 11) |
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| 摘 要： | 目的研究海水浸泡对失血性休克大鼠小肠粘膜上皮细胞线粒体功能的影响。方法采用雄性wistar大鼠24只，分为正常对照组、平原休克组和海水休克组，每组8只。分离小肠粘膜上皮细胞线粒体，检测细胞色素腿aa3、b、c、c1和能荷的水平。结果海水休克组小肠粘膜上皮细胞线粒体细胞色素腿aa3、c、c1和能荷均显著低于对照组和平原休克组。结论海水浸泡失血性休克大鼠小肠粘膜上皮细胞线粒体呼吸链电子传递活性受到全面损伤，能量合成障碍，伤情显著加重。
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| 关 键 词： | 海水浸泡 失血性休克 小肠粘膜 肠上皮细胞 线粒体 大鼠 |
| 文章编号： | 1000-5404(2003)16-1454-02 |
| 修稿时间： | 2003-06-05 |
Effects of sea water immersing on mitochondrial function of intestinal mucosa in hemorrhagic shock rats |
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| YI Yuan xue,LU Song min,LIU Jian cang,SHI Cheng he,LI Ping. Effects of sea water immersing on mitochondrial function of intestinal mucosa in hemorrhagic shock rats[J]. Acta Academiae Medicinae Militaris Tertiae, 2003, 25(16): 1454-1455 |
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| Authors: | YI Yuan xue LU Song min LIU Jian cang SHI Cheng he LI Ping |
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| Abstract: | Objective To study the effects of sea water immersing on mitochondrial function of intestinal mucosa in hemorrhagic shock rats. Methods Twenty four male Wistar rats were divided into 3 groups: control group( n =8), hemorrhagic shock group on land(Group A, n =8) and sea water immersing hemorrhagic shock group(Group B, n =8). Mitochondria were isolated from the intestinal mucosa. Cytochromes aa 3, b, c and c 1 and energy production were determined for the evaluation of the function of respiratory chain of the mitochondria in intestinal mucosa. Results The levels of cytochromes aa 3, c and c 1 and energy production in group B were significantly lower than those in group A and the control group. Conclusion Sea water immersing can damage the function of mitochondria in intestinal mucosa. |
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| Keywords: | seawater hemorrhagic shock intestinal mucosa mitochondria |
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