Colonic manifestations of multiple endocrine neoplasia type 2B |
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| Authors: | Stephen R. Grobmyer M.D. Dr. Jose G. Guillem M.D. Diarmuid S. O'Riordain M.D. James M. Woodruff M.D. Craig Shriver M.D. Murray F. Brennan M.D. |
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| Affiliation: | (1) Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York;(2) Colorectal Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, New York |
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| Abstract: | Multiple endocrine neoplasia type 2B is best known for its endocrine manifestations and typical phenotype. The gastrointestinal manifestations, however, are also an important and commonly unrecognized component of the syndrome. We present four cases that demonstrate the varied presentation of patients with colonic manifestations of multiple endocrine neoplasia type 2B. We discuss the cause, diagnostic significance, and management of the colonic disease that is a component of multiple endocrine neoplasia type 2B. |
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| Keywords: | Constipation Surgery Gastrointestinal tract Ganglioneuromatosis Megacolon Metoclopramide |
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