皮肤伸展术后皮肤超微结构的变化

目的 观察皮肤伸展术后皮肤组织细胞超微结构的变化。方法 分别于实验组皮肤牵张时及实验组、对照组创口缝合后1、2、3、4、6、8周时取皮肤组织块做透射电镜观察，并与正常皮肤相比较。结果 伸展术后皮肤组织超微结构有如下改变：(1)表皮组织：伸展术使细胞间距明显增大，基底细胞长柱状生长、细胞内线粒体和内质网增多、糖元颗粒减少。(2)真皮层内：成纤维细胞内的线粒体和内质网大量增生，真皮内胶元纤维密度增加，上述表现均以伸展术后4周最为显著，6周后开始减弱，8周时仍比对照组明显。相比之下，对照组1～4周也有一定的基底细胞和成纤维细胞代谢合成旺盛表现，但远比实验组为弱。结论 皮肤伸展术能使皮肤组织的超微结构发生明显变化，刺激皮肤组织的生长。

Changes of skin ultrastructure after employing the skin stretch

Objective To observe the changes of skin ultrestructure after the use of skin stretch.?Methods?The skin tissue in test groups were harvested in the period of skin stretch operation,and skin tissues of both test group and control group were harvested in 1,2,3,4,6 and 8 weeks after the operation.?The changes of skin ultrastructure of both groups were observed under the transmission electron microscope,and compared with the normal skin.?Results The alterations of skin ultrastructure were found in two aspects.?In the epidermis,the intercellular space increased significantly and the basal cell shape shifted to column.?The mitochondria and endoplasmic reticulum of both basic cell and fibroblast increased but the number of glycogen granules decreased.?In the dermis,the proliferation of mitochondria and endoplasmic reticulum of fibroblast was significant,and the density of collagen fibers increased simultaneously at fourth week and decreased at sixth week.?At eighth week,these changes were still obviously marked as compared with the control group.?Although there was some productive anabolism both in basal cell and fibroblast,the changes in control group were feebler than those found in the test group.?Conclusion Skin stretch can induce the ultrastructure changes of the skin and stimulate the skin growth.