Assessing intraocular pressure by rebound tonometer in rats with an air-filled anterior chamber |
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| Authors: | Eun Ji Lee Ki Ho Park Dong Myung Kim Young Cheol Yoo Shin Hee Kang Yu Jeong Kim |
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| Affiliation: | (1) Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea;(2) Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea;(3) Department of Ophthalmology, Gangdong Sacred Heart Hospital Hallym University College of Medicine, Seoul, Korea;(4) The Armed Forces Yangju Hospital, Yangju, Korea;(5) Department of Ophthalmology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea |
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| Abstract: | Purpose To compare rebound tonometer and cannulation as methods for measuring intraocular pressure (IOP) in rats. Methods The accuracy of the TonoLab rebound tonometer was determined in eight cannulated rat eyes. IOP was manipulated by changing air pressure from 20 to 100 mmHg at 10-mmHg intervals, and the IOP was measured with the rebound tonometer at each level. The average value of three repeated pressure readings was recorded. Correlation analysis and comparison with the Bland and Altman method were performed. The intraclass correlation coefficient was calculated to assess intraoperator variability. Results The IOP values measured with the TonoLab rebound tonometer were well correlated with the actual IOP (r 2 = 0.963, P = 0.01). The mean of the difference between the rebound tonometer and actual (cannulation) IOP was 7.41 ± 7.87%. The intraclass correlation coefficient was 0.9, indicating low intraoperator variability. Conclusions The rebound tonometer showed high accuracy and reliability for IOP measurement in rat eyes. |
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| Keywords: | cannulation IOP measurement rat rebound tonometer |
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