| 新型免疫抑制因子IL-35研究新进展 |
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| 引用本文： | 岳朝艳,马妍慧,沈立松. 新型免疫抑制因子IL-35研究新进展[J]. 国际免疫学杂志, 2012, 35(1): 18-21 |
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| 作者姓名： | 岳朝艳 马妍慧 沈立松 |
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| 作者单位： | 上海交通大学医学院附属新华医院检验科,200092 |
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| 基金项目： | 上海市自然科学基金资助项目 |
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| 摘 要： | IL-35是一种由调节性T细胞(Tr)分泌具有免疫负调作用的新型细胞因子.IL-35通过抑制IL-17等效应分子发挥免疫调节作用,研究表明,Tr、IL-35和Th17参与了自身免疫性疾病,炎症与肿瘤的免疫调节,因此IL-35的上游激活以及下游效应反应机制值得进一步研究探讨.
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| 关 键 词： | IL-35 调节性T细胞 免疫调节 |
Recent advances in the study of the novel inhibitory cytokine IL-35 |
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| YUE Chao-yan , MA Yan-hui , SHEN li-song. Recent advances in the study of the novel inhibitory cytokine IL-35[J]. International Journal of Immunology, 2012, 35(1): 18-21 |
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| Authors: | YUE Chao-yan MA Yan-hui SHEN li-song |
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| Affiliation: | .( Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092 ; China) |
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| Abstract: | IL-35, a novel inhibitory cytokine, is specifically produced by regulatory T cell （Tr）. It has been proven that IL-35 can negatively regulate the expression of IL-17 and other molecules and plays a role in immune regulation. Studies have shown that Tr, IL-35 and Thl7 are involved in autoimmune diseases, inflammation and tumor immune. Therefore, the mechanism about the activation of IL-35 and its downstream effects should be further studied. |
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| Keywords: | IL-35 regnlatory T cell Immunoloregulation |
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