肿瘤坏死因子-α-308G/A与川崎病遗传易感性的荟萃分析

目的 用荟萃(Meta)分析的方法研究肿瘤坏死因子α(TNF-α)基因启动子区多态位点(-308 G/A)与川崎病(KD)遗传易感性的关系.方法 收集Medline和EMBASE数据库中关于TNF-α-308 G/A与KD遗传易感性的相关文献,对其进行Meta分析.结果 经数据库检索,有4篇文献纳入本研究.对等位基因和基因型频率进行分析,结果显示TNF-α-308 G/A等位基因A的频率与川崎病遗传易感性无显著相关( OR =0.836,95％CI =0.347-2.012).基因型频率与川崎病遗传易感性无显著相关(Aavs.GG,OR=0.817,95％ CI=0.292-2.284；Aavs.GA,OR=0.980,95％ CI=0.300-3.206;AA +GA vs.GG,OR=0.840,95％CI =0.356-1.981;AA+GG vs.AA,OR =0.884,95％CI=0.636-1.227).结论 TNF-α-308 G/A位点基因多态性与川崎病遗传易感性无显著相关,仍需扩大研究样本量进行分析.

A Meta-analysis on tumor necrosis factor-alpha-308G/A and genetic susceptibility for Kawasaki disease

Objective To determine the relationship between tumor necrosis factor-alpha （TNF-α）- 308G/A and Kawasaki disease susceptibility by the method of Meta-analysis. Methods All related literatures about TNF-α-308 G/A and Kawasaki disease had been collected through MEDLINE and EMBASE database, then the data were synthesized and analyzed by Meta-analysis. Results Four literatures about TNF-u-308 G/A and Kawasaki disease were included in the study. Gene effect was assessed using per-allele and per-genotype approaches. The pooled odds ratio of A versus G was 0. 836,95% CI =0. 347-2. 012. The results of genotype effects indicated that the genotype of TNFA -308 G/A was not a risk factor for KD ,AA vs. GG,OR =0. 817, 95% CI =0.292-2. 284;AA vs. GA,OR =0. 980,95% CI --0. 300-3. 206;AA ＋ GA vs. GG,OR = 0.840,95% CI = 0.356-1. 981 ;AA ＋ GG vs. AA, OR = 0. 884,95% CI = 0. 636-1. 227. Conclusion The results indicated that TNF-ct-308 G/A was not associated with Kawasaki disease susceptibility. An updated Meta-analysis is needed if more studies are published.